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Key Documents

MABN502

Sigma-Aldrich

Anti-SNAT1 Antibody, clone N104/37

clone N104/37, from mouse

Synonyme(s) :

Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, rATA1, Glutamine transporter, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System A transporter 2, System N amino acid

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

N104/37, monoclonal

Espèces réactives

mouse, human, rat

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1κ

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC38A1(81539)

Description générale

Sodium-coupled neutral amino acid transporter 1 (SNAT) is also called, Amino acid transporter A1 (ATA1), Glutamine transporter (Glnt), N-system amino acid transporter 2, Solute carrier family 38 member 1 (SLC38A1), System A amino acid transporter 1 (SAT1), System A transporter 2 (SA2), and System N amino acid transporter 1. SNAT functions as a sodium-dependent amino acid transporter that may supply glutamatergic and GABAergic neurons with the glutamine required for the synthesis of the neurotransmitters glutamate and GABA. SNAT is specifically expressed in brain, with the highest levels in cerebellum and thalamus, in glutamatergic, GABAergic and dopaminergic neurons, ependymal cells lining the ventricle and is also detected in spinal cord, heart, colon and placenta.

Spécificité

This antibody recognizes the N-terminus of SNAT1.

Immunogène

Epitope: N-terminus
Recombinant protein corresponding to the N-terminus of rat SNAT1.

Application

Detect Sodium-coupled neutral amino acid transporter 1 using this mouse monoclonal antibody, Anti-SNAT1 Antibody, clone N104/37 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAT1 in rat midbrain and human thalamus tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

Qualité

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SNAT1 in 10 µg of human brain tissue lysate.

Description de la cible

~ 54 kDa observed

Forme physique

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Human brain tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Shanthie Thamotharan et al.
PloS one, 12(5), e0176493-e0176493 (2017-05-04)
Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates perturbed gene expression affecting placental angiogenesis and nutrient transfer from mother to fetus. To understand the post-transcriptional mechanisms underlying such placental gene expression changes, our objective was to identify key non-coding
Karen J Gibbins et al.
Biology of reproduction, 98(5), 695-704 (2018-01-20)
Hypertensive disease of pregnancy (HDP) with placental insufficiency is the most common cause of fetal growth restriction (FGR) in the developed world. Despite the known negative consequences of HDP both to the mother and fetus, little is known about the

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