MABN355

Anti-HAND2 Antibody, Clone 7D4.1

clone 7D4.1, from mouse

• Synonyme(s) : Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 7D4.1, monoclonal
• Espèces réactives: human, mouse
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_068808
• Numéro d'accès UniProt: P61296
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HAND2(9464)

Description

Description générale

Heart-and neural crest derivatives-expressed protein 2 , also known as Class A basic helix-loop-helix protein 26 (bHLHa26), or Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), and encoded by the gene HAND2/BHLHA26/DHAND, is a transcription factor that is essential for cardiac morphogenesis, particularly the formation of the right ventricle and the aortic arch arteries. Heart-and neural crest derivatives-expressed protein 2 is required for vascular development, angiogenesis and for limb development acting upstream of sonic hedgehog in the induction of the limb bud. Additionally, Heart-and neural crest derivatives-expressed protein 2 is central to cardiac neural crest cell development and involved in outflow tract morphogenesis as well as the maintenance of the adult heart and in the negative regulation of cardiac muscle cell apoptosis. Heart-and neural crest derivatives-expressed protein 2 is localized to the nucleus. Heart-and neural crest derivatives-expressed protein 2 is expressed in developing heart, lung and vascular system.

Immunogène

Epitope: C-terminus outside the bHLH domain

Recombinant protein corresponding to the C-terminus outside the bHLH domain of human HAND2.

Application

Detect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HAND2 in human placenta tissue.

Qualité

Evaluated by Western Blotting in mouse heart tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected HAND2 in 10 µg of mouse heart tissue lysate.

Description de la cible

~30 kDa observed

Forme physique

Format: Purified

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable