MABN263

Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8

clone 10F10-C1-B8, from mouse

• Synonyme(s) : Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 10F10-C1-B8, monoclonal
• Espèces réactives: rat
• Technique(s): immunocytochemistry: suitable; western blot: suitable
• Isotype: IgG2bκ
• Numéro d'accès NCBI: NP_899156
• Numéro d'accès UniProt: P18508
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: rat ... Gabrg2(29709)

Description

Description générale

GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

Immunogène

Linear peptide corresponding to rat GABA(A) receptor subunit gamma-2.

Application

Detect GABA(A) receptor subunit gamma-2 using this Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8 validated for use in Western Blotting, ICC.

Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected GABA(A) receptor subunit gamma-2 in rat hippocampal neurons. Image courtesy from the laboratory of Dr. Jaideep Kapur, University of Virginia.

Qualité

Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 in 10 µg of PC-12 cell lysate.

Description de la cible

~54 kDa observed

Forme physique

Format: Purified

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable