ABN117

Anti-PDE4D3 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, DPDE3, PDE43
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: rat, mouse, rhesus macaque
• Réactivité de l'espèce (prédite par homologie): human (immunogen homology), rhesus monkey (based on 100% sequence homology)
• Technique(s): western blot: suitable
• Numéro d'accès NCBI: NP_006194
• Numéro d'accès UniProt: Q08499
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PDE4D(5144)

Description

Description générale

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

Spécificité

This antibody recognizes PDE4D3 at the N-terminus.

Immunogène

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.

Application

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

Qualité

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate.

Description de la cible

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

Forme physique

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Mouse brain membrane tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable