ABE1082

Anti-JARID1C Antibody

from rabbit

• Synonyme(s) : Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Espèces réactives: human
• Technique(s): western blot: suitable
• Numéro d'accès NCBI: NP_001140174
• Numéro d'accès UniProt: P41229
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KDM5C(8242)

Description

Description générale

JARID1C, also known as Jumonji/ARID domain-containing protein 1C, Protein SmcX, or Protein Xe169, and encoded by the gene KDM5C/DXS1272E/JARID1/SMCX/XE169, a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. JARID1C demethylates trimethylated and dimethylated but not monomethylated H3 ′Lys-4′. JARID1C does not demethylate histone H3 ′Lys-9′, H3 ′Lys-27′, H3 ′Lys-36′, H3 ′Lys-79′ or H4 ′Lys-20′. Additionally, JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. JARID1C is localized to the nucleus. Defects in JARID1C are associated with Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) disorder. MRXSCJ patients have below average general intellectual functioning associated with impairments in adaptive behavior during development, and suffer mental retardation, progressive spastic paraplegia, seizures, and facial dysmorphism.

Immunogène

Linear peptide corresponding to human JARID1C.

Application

Anti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Qualité

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected JARID1C in 10 µg of HEK293 cell lysate.

Description de la cible

~175 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Forme physique

Format: Purified

Protein A purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1