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AB10516

Sigma-Aldrich

Anti-Angiopoietin-1 Antibody

from rabbit

Synonyme(s) :

Hepatic fibrinogen/angiopoietin-related protein, PPARG angiopoietin related protein, angiopoietin-like 4, angiopoietin-like 4 protein, angiopoietin-related protein 4, fasting-induced adipose factor, hepatic angiopoietin-related protein, peroxisome prolif

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

horse (95% sequence homology), dog (95% sequence homology), mouse (100% sequence homology), rat (95% sequence homology), bovine (95% sequence homology), mouse, human (90% sequence homology), pig (95% sequence homology)

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NM_001146.3

Numéro d'accès UniProt

O08538

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ANGPT1(284)

Description générale

The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic development, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology.

Spécificité

This antibody recognizes Angiopoietin-1.

Immunogène

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from mouse Angiopoietin-1.

Application

Anti-Angiopoietin-1 Antibody is an antibody against Angiopoietin-1 for use in WB.

Qualité

Evaluated by Western Blot in mouse kidney lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Angiopoietin-1 on 10 µg of mouse kidney lysate.

Description de la cible

57 kDa

Forme physique

Format: Purified

Remarque sur l'analyse

Control
Mouse kidney lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yu Zhan et al.
Frontiers in neuroscience, 13, 701-701 (2019-07-30)
Xiaoshuan enteric-coated capsule (XSEC) is a Chinese medicinal compound widely used for treatment of ischemic cerebrovascular diseases. Enriched environment (EE) is an effective rehabilitative protocol designed to enhance sensorimotor, cognitive and social stimulation. This study aimed to apply magnetic resonance
Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes.
Feng, et al.
Frontiers in Cellular Neuroscience, 17, 1125412-1125412 (2023)
Mansoor Syed et al.
Nature communications, 8(1), 1173-1173 (2017-10-29)
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or therapeutic agent is available. Here we show that lung micro-RNA (miR)-34a levels are significantly increased in
Angara Sureshbabu et al.
Respiratory research, 16, 4-4 (2015-01-17)
Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms responsible for
Defang Pang et al.
Experimental & molecular medicine, 50(9), 117-117 (2018-09-07)
We have previously demonstrated that in response to cerebral ischemia (CI), the growth factor angiopoietin-1 (Ang1) and α5β1 integrin are both induced in cerebral vessels, which likely provide positive signals driving the endogenous angiogenic response and vascular protection after CI.
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