382425
Trequinsin, Hydrochloride
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro.
Synonyme(s) :
Trequinsin, Hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
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| Taille/Référence | Disponibilité | Prix |
|---|---|---|
10 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 422,00 $ |
A propos de cet article
422,00 $
Quality Segment
description
RTECS - UW7727000
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
pale yellow
solubility
water: 500 μM
shipped in
ambient
storage temp.
10-30°C
SMILES string
Cl.[n]21c(c[c]([n]([c]2=O)C)=Nc4c(cc(cc4C)C)C)c3c(cc(c(c3)OC)OC)CC1
InChI
1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H
InChI key
DTCZZBVPTHVXFA-UHFFFAOYSA-N
General description
Biochem/physiol Actions
cGMP-inhibited phosphodiesterase
Preparation Note
Other Notes
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Legal Information
Disclaimer
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Cet article | |||
|---|---|---|---|
| description Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. | description A non-specific phospholipase A2 (PLA2) inhibitor. | description Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). | description ≥98% |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99% (HPLC) | assay ≥98% |
| form solid | form solid | form crystalline solid | form powder |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 10-30°C | storage temp. 10-30°C | storage temp. 10-30°C | storage temp. - |
| storage condition desiccated, OK to freeze | storage condition desiccated (hygroscopic), OK to freeze, protect from light | storage condition desiccated (hygroscopic), OK to freeze | storage condition - |
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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