361569

GSK-3beta Inhibitor XXVI - Calbiochem

• Synonyme(s) : GSK-3beta Inhibitor XXVI - Calbiochem
• Formule empirique (notation de Hill): C₂₁H₁₈N₄O
• Poids moléculaire : 342.39
• Numéro MDL: MFCD28144508
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥95% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 50 mg/mL, light yellow
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

This product has been discontinued.

A cell-permeable, pyrazolone GSK-3β inhibitor (IC₅₀ = 34 nM, in an enzymatic assay) that is highly selective among a panel of 40 kinases that have been profiled with more than 50 fold selectivity. It exhibits no off-target activity against a panel of 44 human and rodent CNS receptors, channels, and transporters except for some modest activity toward 5HT1a. It demonstrates neuroprotective activity of neurons in an oxidative stress model induced by homocysteic acid (HCA) from 1–20 µM, without observable cytotoxicity, and is superior to SB-216763 Cat. No. 361566) at 5 µM in cell micrographs. In addition, it is shown to attenuate locomotor activity in an chlordiazepoxide/amphetamine-induced hyperactivity mice model in vivo at 150 mg/kg.

A cell-permeable, pyrazolone GSK-3β inhibitor (IC₅₀ = 34 nM, in an enzymatic assay) that is highly selective among a panel of 40 kinases that have been profiled with more than 50 fold selectivity. It exhibits no off-target activity against a panel of 44 human and rodent CNS receptors, channels, and transporters except for some modest activity toward 5HT1a. It demonstrates neuroprotective activity of neurons in an oxidative stress model induced by homocysteic acid (HCA) from 1–20 µM, without observable cytotoxicity, and is superior to SB-216763 Cat. No. 361566) at 5 µM in cell micrographs. In addition, it is shown to attenuate locomotor activity in an chlordiazepoxide/amphetamine-induced hyperactivity mice model in vivo at 150 mg/kg.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Chen, W., et al. 2011. ChemMedChem6, 1587.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10-13 - German Storage Class 10 to 13