328006-M

ERK Inhibitor

The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : ERK Inhibitor, 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
• Formule empirique (notation de Hill) : C₁₄H₁₆N₂O₃S · xHCl
• Numéro CAS: 1049738-54-6
• Poids moléculaire : 292.35 (free base basis)
• Numéro MDL: MFCD09038681
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: light yellow
• Solubilité: DMSO: 10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: S1C(=O)N(C(=O)C1=Cc2ccc(cc2)OCC)CCN.Cl
• Clé InChI: PQVLWVGMXJPJLG-UHFFFAOYSA-N

Description

Description générale

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Actions biochimiques/physiologiques

Primary Target
ERK

Target IC₅₀: ≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Hancock, C. N., et al. 2005. J. Med. Chem.48, 4586.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable