182015

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Potent inhibitor of cell adhesion.

• Synonyme(s) : Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
• Formule empirique (notation de Hill): C₂₆H₃₈N₈O₇
• Numéro CAS: 137813-35-5
• Poids moléculaire : 574.63
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: 1 N acetic acid: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable