14-404-M
ZAP-70 Protein, active, 20 µg
Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.
Synonyme(s) :
70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
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About This Item
Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.32
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in Sf21 cells
Forme
liquid
Durée de conservation
6 mo.
Poids mol.
Mw 70 kDa
Fabricant/nom de marque
Upstate®
Technique(s)
activity assay: suitable (kinase)
Numéro d'accès NCBI
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... ZAP70(7535)
Description générale
Research area: CELL SIGNALING
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Actions biochimiques/physiologiques
Protein Target: ZAP-70
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Qualité
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
Forme physique
Ni2+/NTA-agarose
Stockage et stabilité
6 months at -20C
Autres remarques
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Experimental Models for Rheumatoid Arthritis
Rikard Holmdahl
Journal of Separation Science, 400-412 (2013)
ZAP-70: an essential kinase in T-cell signaling
Wang H, et al.
Cold Spring Harbor Perspectives in Biology, 2(5), a002279-a002279 (2010)
The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
Huber RG, et al.
PLoS Computational Biology, 11(10), e1004560-e1004560 (2015)
ZAP-70 in Signaling, Biology, and Disease
Au-Yeung BB, et al.
Annual Review of Immunology, 36, 127-156 (2018)
D H Chu et al.
Immunological reviews, 165, 167-180 (1998-12-16)
The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein
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