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N-005

Supelco

Norcodeine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C17H19NO3
Numéro CAS:
Poids moléculaire :
285.34
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

forensics and toxicology

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

COc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)[C@@H](O)C=C[C@@H]35

InChI

1S/C17H19NO3/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16/h2-5,10-12,16,18-19H,6-8H2,1H3/t10-,11+,12-,16-,17-/m0/s1

Clé InChI

HKOIXWVRNLGFOR-KOFBORESSA-N

Description générale

Norcodeine is a primary urinary metabolite of codeine. Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications from urine drug testing and pain prescription monitoring to clinical toxicology and forensic analysis.

Application

  • Pharmacokinetics and nociceptive effects of codeine in horses: A study conducted by Knych HK et al., investigated the pharmacokinetics and the effects on thermal nociception in horses following the administration of codeine. This research provides valuable data for understanding how opioid metabolites like norcodeine behave in non-human subjects, aiding in veterinary pharmacological applications (Knych et al., 2022).
  • Opioid metabolite analysis in forensic toxicology: Jakobsson G and colleagues developed a method using LC-MS/MS to analyze heroin-related compounds, including norcodeine, in postmortem samples. This research is crucial for forensic investigations, providing detailed insights into the metabolite profiles that can assist in the detection and analysis of opioid abuse cases (Jakobsson et al., 2021).
  • Analysis of opioid metabolites in forensic cases: Feliu C et al. presented a technique for quantifying various opioids and their derivatives, such as norcodeine, in whole blood using liquid chromatography-high-resolution mass spectrometry. This method is significant for forensic science, contributing to the accurate assessment of substances involved in fatal cases (Feliu et al., 2020).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameSkull and crossbonesHealth hazard

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Z R Chen et al.
Journal of chromatography, 491(2), 367-378 (1989-07-21)
A novel high-performance liquid chromatographic method for the determination of codeine, norcodeine and morphine in plasma and urine has been developed. The compounds were separated on a cyano column (15 cm x 4.6 mm, 5 microns particle size) using a
[Morphinan alkaloids present in mammal].
Y M Ning et al.
Sheng li ke xue jin zhan [Progress in physiology], 21(4), 329-332 (1990-10-01)
J O Svensson et al.
Journal of chromatography. B, Biomedical applications, 674(1), 49-55 (1995-12-01)
A reversed-phase ion-pair high-performance liquid chromatographic method for the simultaneous determination of codeine and seven metabolites is described. The samples are purified by reversed-phase solid-phase extraction. Codeine, norcodeine, codeine-6-glucuronide, norcodeine-6-glucuronide and morphine-3-glucuronide are measured with UV detection. Detection limits are
M Pawula et al.
Journal of chromatography. B, Biomedical applications, 653(1), 106-111 (1994-02-18)
A rapid and sensitive HPLC method has been developed for the determination of codeine, norcodeine and morphine in small volumes of a biological matrix, using a cyanopropyl column and a combination of coulometric and UV detection. The compounds were isolated
Hicham Kharbouche et al.
International journal of legal medicine, 122(3), 205-211 (2007-12-08)
The aim of this study was to evaluate the reliability of insect larvae as samples for toxicological investigations. For this purpose, larvae of Lucilia sericata were reared on samples of minced pig liver treated with different concentrations of codeine: therapeutic

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