D-902

Diazepam-d₅ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₆D₅H₈ClN₂O
• Numéro CAS: 65854-76-4
• Poids moléculaire : 289.77
• Numéro CE : 200-659-6
• Numéro MDL: MFCD00070151
• Code UNSPSC : 41116107
• ID de substance PubChem : 329798886
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• Concentration: 100 μg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: O=C1CN=C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C3=C(C=CC(Cl)=C3)N1C
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3/i2D,3D,4D,5D,6D
• Clé InChI: AAOVKJBEBIDNHE-VIQYUKPQSA-N

Description

Description générale

Diazepam is a benzodiazepine used to treat a number of symptoms from anxiety and panic attacks to insomnia. This stable-labeled internal standard is suited for quantitation of diazepam levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis, or isotope dilution methods. Diazepam, a benzodiazpine frequently abused recreationally, is sold under the trade name Valium^®.

Application

• Diazepam-d₅ internal standard: Research on clomiphene in keratinous matrices utilized Diazepam-d₅ as an internal standard in LC-MS/MS analysis, demonstrating its essential role in ensuring precision and reliability in forensic toxicology (Kintz et al., 2023).


• Stable isotope-labeled Diazepam: A forensic study highlighted the use of Diazepam-d₅ in confirming the presence of drugs in decomposed cadavers, showcasing its importance in providing corroborative evidence in cases of serial homicides (Ottaviano et al., 2021).


• Diazepam-d₅ for analytical research: The postmortem analysis of benzodiazepines in human bone by gas chromatography-mass spectrometry employed Diazepam-d₅, demonstrating its effectiveness as a reference material for accurate drug quantification (Mancini et al., 2021).


• Diazepam-d₅ in pharmacological studies: Method development for quantitative determination of statins highlighted the use of Diazepam-d₅ in tandem mass spectrometry, underlining its utility in adherence testing and therapeutic drug monitoring (Wagmann et al., 2020).


• Diazepam-d₅ in receptor binding studies: An evaluation of benzodiazepines and zolpidem in nails and their stability in chlorinated water demonstrated Diazepam-d₅′s role as a robust analytical standard, critical for ensuring the integrity of pharmacological assays (Moretti et al., 2018).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Valium is a registered trademark of Roche Products Inc.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup