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Documents

ALD00550

Serine Hydrolase Inhibitor-17

Name: Serine Hydrolase Inhibitor-17
Brand: ALDRICH

Synonyme(s) :

tert-Butyl 4-(1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate, SHI-17

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About This Item

Formule empirique (notation de Hill):

C₁₄H₂₂N₄O₃

Numéro CAS:

1622426-20-3

Poids moléculaire :

294.35

Code UNSPSC :

12352200

ID de substance PubChem :

329772714

Nomenclature NACRES :

NA.22

Forme

solid

Niveau de qualité

100

Chaîne SMILES

O=C(N1CCCN(C(OC(C)(C)C)=O)CC1)N2N=CC=C2

InChI

1S/C14H22N4O3/c1-14(2,3)21-13(20)17-8-5-7-16(10-11-17)12(19)18-9-4-6-15-18/h4,6,9H,5,7-8,10-11H2,1-3H3

Clé InChI

SREDUUSCWDQNQK-UHFFFAOYSA-N

Application

Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine hydrolase class of proteins. They are amenable to further modification to create novel inhibitors of this class of protein.

Pictogrammes

GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Conseils de prudence

P301 + P330 + P331 + P310

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Discovery libraries targeting the major enzyme classes: the serine hydrolases.

Katerina Otrubova et al.

Bioorganic & medicinal chemistry letters, 24(16), 3807-3813 (2014-07-20)

Two libraries of modestly reactive ureas containing either electron-deficient acyl anilines or acyl pyrazoles were prepared and are reported as screening libraries for candidate serine hydrolase inhibitors. Within each library is a small but powerful subset of compounds that serve

Contenu apparenté

Boger Group – Professor Product Portal

As the exploration of the properties of complex natural products becomes increasingly more sophisticated with the technological advances being made in their screening and evaluation and as structural details of their interaction with biological targets becomes more accessible, the importance and opportunities for providing unique solutions to complex biological problems has grown. The Boger Lab addresses these challenging problems by understanding the complex solutions and subtle design elements that nature has provided in the form of a natural product and work to extend the solution through rational design elements to provide more selective, more efficacious, or more potent agents designed specifically for the problem or target under investigation. The resulting efforts have reduced many difficult or intractable synthetic challenges to manageable problems providing an approach not only to the natural product but one capable of simple extrapolation to a series of structural analogs with improved selectivity and efficacy.

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