Accéder au contenu
MilliporeSigma
Toutes les photos(1)

Principaux documents

54802

Sigma-Aldrich

1-Hydroxybenzotriazole hydrate

≥97.0% dry basis (T), for peptide synthesis

Synonyme(s) :

HOBt Hydrate

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

10 G
41,90 $
50 G
143,00 $
250 G
488,00 $

41,90 $


En stockDétails


Devis pour commande en gros

Sélectionner une taille de conditionnement

Changer de vue
10 G
41,90 $
50 G
143,00 $
250 G
488,00 $

About This Item

Formule empirique (notation de Hill):
C6H5N3O · xH2O
Numéro CAS:
Poids moléculaire :
135.12 (anhydrous basis)
Beilstein:
4515
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352000
ID de substance PubChem :
Nomenclature NACRES :
NA.22

41,90 $


En stockDétails


Devis pour commande en gros

Nom du produit

1-Hydroxybenzotriazole hydrate, ≥97.0% dry basis (T)

Niveau de qualité

Essai

≥97.0% dry basis (T)

Forme

solid

Composition

water, ~12%

Capacité de réaction

reaction type: Addition Reactions

Pf

155-158 °C (lit.)

Solubilité

DMF: 0.1 g/mL, clear

Application(s)

peptide synthesis

Chaîne SMILES 

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

Clé InChI

PJUPKRYGDFTMTM-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids.[1] It is also used as a racemization suppressor during peptide synthesis.[2]

Application

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
  • Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.[2]
  • Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.[3]

Autres remarques

Widely used additive to decrease racemization in the carbodiimide peptide coupling;[4] Racemization-free condensation of peptide fragments[5][6]

Pictogrammes

FlameExclamation mark

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

Code de la classe de stockage

4.1A - Other explosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

314.6 °F

Point d'éclair (°C)

157 °C


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

T. Miyazawa et al.
Tetrahedron Letters, 25, 771-771 (1984)
Oxyma-B, an excellent racemization suppressor for peptide synthesis
Jad YE, et al.
Organic & Biomolecular Chemistry, 12(42), 8379-8385 (2014)
Chemical synthesis of poly-?-glutamic acid by polycondensation of ?-glutamic acid dimer: Synthesis and reaction of poly-?-glutamic acid methyl ester
Sanda F, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 39(5), 732-741 (2001)
Synthesis of 3, 5-disubstituted 1, 2, 4-oxadiazoles and their behavior of liquid crystallines
Guo J, et al.
Tetrahedron Letters, 55(9), 1557-1560 (2014)
S. Ishizuka et al.
Pept. Sci., 37, 39-39 (2001)

Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique