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47296

o-Fluoro-L-phenylalanine

Name: <I>o</I>-Fluoro-<SC>L</SC>-phenylalanine
Brand: ALDRICH

puriss., ≥99.0% (sum of enantiomers, HPLC)

Synonyme(s) :

2-Fluoro-L-phenylalanine

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About This Item

Formule empirique (notation de Hill):

C₉H₁₀FNO₂

Numéro CAS:

19883-78-4

Poids moléculaire :

183.18

Beilstein:

2805791

Numéro MDL:

MFCD00066448

Code UNSPSC :

12352200

ID de substance PubChem :

24870852

Qualité

puriss.

Essai

≥99.0% (sum of enantiomers, HPLC)

Activité optique

[α]20/D −14±1°, c = 1% in H₂O

Pureté optique

enantiomeric ratio: ≥99.5:0.5 (TLC)

Chaîne SMILES

N[C@@H](Cc1ccccc1F)C(O)=O

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

264687/1

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Structure-activity relationships among substituted N-benzoyl derivatives of phenylalanine and its analogs in a microbial antitumor prescreen I: Derivatives of o-fluoro-DL-phenylalanine.

T T Otani et al.

Journal of pharmaceutical sciences, 71(2), 214-216 (1982-02-01)

Twelve derivatives of 0-fluoro-dl-phenylalanine containing fluorine, chlorine, methoxy, and nitro radicals in various positions of the aromatic ring of the benzoyl group were prepared and tested in a Lactobacillus casei system. It was found that most substitutions in the benzoyl

Enantioseparation of amino acids, alpha-hydroxy acids, and dipeptides by ligand-exchange CEC using silica-based chiral stationary phases.

Elfriede Pittler et al.

Electrophoresis, 30(16), 2897-2904 (2009-08-06)

This work deals with the application of silica-based ligand-exchange chiral stationary phases (CSPs) for the enantioseparation of underivatized amino acids, alpha-hydroxy acids, and dipeptides with packed CEC. Two different possibilities of preparing silica-based CSPs are presented. One phase contains L-4-hydroxyproline

Does the anabolic metabolism of L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine differ in the cerebrum and the cerebellum?

H Nakamichi et al.

Nuclear medicine and biology, 21(7), 959-962 (1994-10-01)

The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between

Enantiospecific synthesis of 2-[18F]fluoro-L-phenylalanine and 2-[18F]fluoro-L-tyrosine by isotopic exchange.

Johnny Castillo Meleán et al.

Organic & biomolecular chemistry, 9(3), 765-769 (2010-11-23)

2-[(18)F]Fluoro-L-phenylalanine and 2-[(18)F]fluoro-L-tyrosine have been developed as promising radiopharmaceuticals for molecular imaging using positron emission tomography (PET). However, the lack of a convenient radiosynthetic pathway has limited their practical use. In this work a new three-step nucleophilic synthesis of these

Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative.

Kensuke Okuda et al.

Biochemistry, 44(17), 6675-6684 (2005-04-27)

The ribosome-catalyzed peptidyl transferase reaction displays a complex pH profile resulting from two functional groups whose deprotonation is important for the reaction, one within the A-site substrate and a second unidentified group thought to reside in the rRNA peptidyl transferase

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