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348147

Sarsasapogenin

Name: Sarsasapogenin
Brand: ALDRICH

95%

Synonyme(s) :

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Formule empirique (notation de Hill) :

C₂₇H₄₄O₃

Numéro CAS:

126-19-2

Poids moléculaire :

416.64

Numéro MDL:

MFCD00270414

Code UNSPSC :

12352200

ID de substance PubChem :

329755058

Essai

95%

Forme

solid

Chaîne SMILES

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

Clé InChI

GMBQZIIUCVWOCD-WWASVFFGSA-N

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Certificats d'analyse (COA)

Lot/Batch Number

07202HW

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Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus.

Bomi Lee et al.

Immunopharmacology and immunotoxicology, 32(3), 357-363 (2010-01-26)

To investigate the antiallergic effect of the rhizome of Anemarrhena asphodeloides (AA, family Liliaceae), which was found to inhibit the mouse passive cutaneous anaphylaxis (PCA) reaction induced by the antigen-immunoglobulin E (IgE) complex in preliminary experiments, main steroidal saponins, timosaponins

Antiviral activity of Solanum paniculatum extract and constituents.

Ydia M Valadares et al.

Zeitschrift fur Naturforschung. C, Journal of biosciences, 64(11-12), 813-818 (2010-02-18)

Solanum species are traditionally employed as antiherpes and anticancer agents in different countries. S. paniculatum has widespread ethnomedical uses in Brazil, including the treatment of viral infections. This paper reports on the isolation of neotigogenin (1) and the new compound

Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor.

R Zhang et al.

Neuroscience, 210, 275-285 (2012-03-24)

The development of drugs that attenuate neurodegeneration is important for the treatment of Alzheimer's disease (AD). We previously found that smilagenin (SMI), a steroidal sapogenin from traditional Chinese medicinal herbs improves memory in animal models, is neither a cholinesterase inhibitor

An improved facile method for extraction and determination of steroidal saponins in Tribulus terrestris by focused microwave-assisted extraction coupled with GC-MS.

Tianlin Li et al.

Journal of separation science, 32(23-24), 4167-4175 (2009-11-06)

An improved fast method for extraction of steroidal saponins in Tribulus terrestris based on the use of focus microwave-assisted extraction (FMAE) is proposed. Under optimized conditions, four steroidal saponins were extracted from Tribulus terrestris and identified by GC-MS, which are

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.

Naomi P Visanji et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(7), 2488-2497 (2008-03-28)

Many experimental data support the enhancement of neurotrophic factors as a means to modify neurodegeneration in Parkinson's disease. However, the translation of this to the clinic has proven problematic. This is likely due to the complex nature of the surgical

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