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286818

Neostigmine methyl sulfate

Name: Neostigmine methyl sulfate
Brand: ALDRICH

98%

Synonyme(s) :

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium methyl sulfate

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About This Item

Formule empirique (notation de Hill):

C₁₃H₂₂N₂O₆S

Numéro CAS:

51-60-5

Poids moléculaire :

334.39

Numéro CE :

200-109-5

Numéro MDL:

MFCD00011796

Code UNSPSC :

12352103

Pureté

98%

Chaîne SMILES

COS([O-])(=O)=O.CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

InChI

1S/C12H19N2O2.CH4O4S/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;1-5-6(2,3)4/h6-9H,1-5H3;1H3,(H,2,3,4)/q+1;/p-1

Clé InChI

OSZNNLWOYWAHSS-UHFFFAOYSA-M

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Actions biochimiques/physiologiques

Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.

Pictogrammes

GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H300,H315,H319,H334,H335

Conseils de prudence

P261 - P264 - P301 + P310 - P305 + P351 + P338 - P342 + P311

Classification des risques

Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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[Anticholinesterases; peripheral and central effects].

Tetsufumi Sato et al.

Masui. The Japanese journal of anesthesiology, 62(1), 19-26 (2013-02-26)

Anticholinesterase, such as neostigmine, was used to be a standard drug at the end of surgery for reversal of nondepolarizing neuromuscular block. Neostigmine decreases the metabolism of acetylcholine (ACh) at the neuromuscular junction and allows its concentration to increase and

A prospective, observational study comparing postoperative residual curarisation and early adverse respiratory events in patients reversed with neostigmine or sugammadex or after apparent spontaneous recovery.

G V Cammu et al.

Anaesthesia and intensive care, 40(6), 999-1006 (2012-12-01)

Six years ago, a study performed in our department reported that the incidence of postoperative residual curarisation (PORC) was 39%. The reassessment of neuromuscular monitoring and reversal of neuromuscular block in routine anaesthetic practice is relevant now that sugammadex has

New neostigmine-based behavioral mouse model of abdominal pain.

Jakub Fichna et al.

Pharmacological reports : PR, 64(5), 1146-1154 (2012-12-15)

Animal models of visceral pain have gained much attention as an important tool to elucidate the possible mechanisms underlying functional gastrointestinal (GI) disorders. Here we report the development of a new, minimally invasive behavioral model of abdominal pain induced by

The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system.

Oyun Khookhor et al.

Neuro endocrinology letters, 34(1), 58-61 (2013-03-26)

We previously demonstrated that the direct microinjection of cholinesterase inhibitor (neostigmine) into the hippocampus in rats activated the hypothalamo-pituitary -adrenal axis and increased the level of norepinephrine in the plasma. In the current study we tried to measure the effects

Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.

Martina Grosse-Sundrup et al.

BMJ (Clinical research ed.), 345, e6329-e6329 (2012-10-19)

To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications. Prospective, propensity score matched cohort study. General teaching hospital in Boston, Massachusetts, United States, 2006-10. 18,579 surgical patients who received

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