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Sigma-Aldrich

Aldrithiol™-4

98%

Synonyme(s) :

4,4′-Dipyridyl disulfide, 4,4′-Dithiodipyridine

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About This Item

Formule empirique (notation de Hill):
C10H8N2S2
Numéro CAS:
2645-22-9
Poids moléculaire :
220.31
Numéro CE :
220-158-6
Numéro MDL:
MFCD00006423
Code UNSPSC :
12352100
ID de substance PubChem :
24848571
Nomenclature NACRES :
NA.22

Pureté

98%

Forme

solid

Pf

76-78 °C (lit.)

Solubilité

95% ethanol: soluble 5%, clear, colorless to light yellow

Température de stockage

2-8°C

Chaîne SMILES 

S(Sc1ccncc1)c2ccncc2

InChI

1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H

Clé InChI

UHBAPGWWRFVTFS-UHFFFAOYSA-N

Application

  • Aldrithiol™-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
  • It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
  • It was used to modify gold surfaces for protein studies.

Informations légales

Aldrithiol is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Leonid S Brown et al.
Journal of molecular biology, 317(3), 471-478 (2002-04-02)
The conformation of the structured EF interhelical loop of bacteriorhodopsin and its change in the M photointermediate were assessed by measuring the rate of reaction of 16 single engineered cysteine residues along the loop with water-soluble sulfhydryl reagents. The exposure
Nikitas Bistolas et al.
Biochemical and biophysical research communications, 314(3), 810-816 (2004-01-27)
The spectroelectrochemistry of camphor-bound cytochrome P450cam (P450cam) using gold electrodes is described. The electrodes were modified with either 4,4(')-dithiodipyridin or sodium dithionite. Electrolysis of P450cam was carried out when the enzyme was in solution, while at the same time UV-visible
Shwu-Jiuan Sheu et al.
Investigative ophthalmology & visual science, 44(3), 1237-1244 (2003-02-26)
To identify the mechanisms by which oxidative stress with oxidizing agents alters the activity of ion channels in human retinal pigment epithelial (RPE) cells. The effects of oxidizing agents on ion currents were investigated in human RPE R-50 cells with
Iveta Imriskova-Sosova et al.
Biochemistry, 44(51), 16949-16956 (2005-12-21)
Members of the Sco protein family are implicated in the assembly of the respiratory complex cytochrome c oxidase. Several possible roles have been proposed for Sco: a copper delivery agent, a site-specific thiol reductase, and an indicator of cellular redox
Soong-Yu Kuo et al.
Archives of toxicology, 77(11), 630-637 (2003-08-21)
The effect of oxidants on Ca(2+) movement in osteoblasts is unclear. In this study, we show that 4,4'-dithiodipyridine (4,4'-DTDP), a reactive disulphide that mobilizes Ca(2+) in muscle, induces an increase in cytoplasmic free-Ca(2+) concentrations ([Ca(2+)](i)) in MG63 human osteosarcoma cells
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