TYMS
thymidylate synthetase
Synonymes:
HST422, TMS, TS
Espèce(s):
Human TYMS (7298), Mouse Tyms (22171), Rat Tyms (29261), naked mole-rat Tyms (101721263), domestic guinea pig Tyms (100720541), Zebrafish tyms (81540), chicken TYMS (421060), cow TYMS (507631), domestic cat TYMS (101091231), dog TYMS (607417)
ID UniProtKB:
ID du gène:
- Human(7298) Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
- Mouse(22171) thymidylate synthase
- Rat(29261) thymidylate synthetase
- naked mole-rat(101721263) thymidylate synthetase
- domestic guinea pig(100720541) thymidylate synthetase
- Zebrafish(81540) thymidylate synthase
- chicken(421060) thymidylate synthetase
- cow(507631) thymidylate synthetase
- domestic cat(101091231) thymidylate synthetase
- dog(607417) thymidylate synthetase
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-TYMS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TYMS Antibody, clone 1E20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey, porcine, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-TYMS antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Monoclonal Anti-TYMS antibody produced in mouse, clone 3A1, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-TYMS antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
5-Fluoro-2′-désoxyuridine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human