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TRPV4

transient receptor potential cation channel, subfamily V, member 4

Synonymes:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Espèce(s)
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Espèce(s)
rat

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Capsazepine, ≥98% (HPLC), solid,
Espèce(s)
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Espèce(s)
rat, human
Capsaicin, natural,
Espèce(s)
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Espèce(s)
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Espèce(s)
human, rat, mouse

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
canine, human, mouse, rat
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Trpv4 Antibody, clone 1B2.6, clone 1B2.6, from mouse,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
rat
Application
western blot
Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain, Chemicon®, from rabbit,
Espèces réactives
rat
Application
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, rabbit
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Butamben, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Capsaicin, ≥95%, from Capsicum sp.,
Espèce(s)
rat, human
Capsaicin, natural,
Espèce(s)
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Espèce(s)
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Espèce(s)
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
N-Vanillylnonanamide, ≥97%, powder,
Espèce(s)
rat
Capsazepine, ≥98% (HPLC), solid,
Espèce(s)
human, rat

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Trpv4,
Espèce(s)
mouse
MISSION® esiRNA, targeting human TRPV4,
Espèce(s)
human