TEK
TEK tyrosine kinase, endothelial
Synonymes:
CD202B, TIE-2, TIE2, VMCM, VMCM1
Espèce(s):
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), chicken TEK (427368), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
ID UniProtKB:
ID du gène:
- Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
- Mouse(21687) endothelial-specific receptor tyrosine kinase
- Rat(89804) TEK tyrosine kinase, endothelial
- chicken(427368) TEK tyrosine kinase, endothelial
- Zebrafish(30747) TEK tyrosine kinase, endothelial
- dog(403714) TEK tyrosine kinase, endothelial
- domestic cat(101091977) TEK tyrosine kinase, endothelial
- cow(280939) TEK tyrosine kinase, endothelial
- domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
- naked mole-rat(101710501) TEK tyrosine kinase, endothelial
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ELISA
Référence du produit
Description
Espèce(s)
Human Tie-2 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Espèce(s)
human
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Tie2/TEK Antibody, clone Ab33, clone Ab33, Upstate®, from mouse,
Espèces réactives
human, mouse, pig, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-phospho TIE2/TEK Antibody (Tyr992), 0.25 mg/mL, from rabbit,
Espèces réactives
bovine, human, mouse, rat, zebrafish
Application
immunoprecipitation (IP)
inhibition assay
western blot
inhibition assay
western blot
ANTI-TEK antibody produced in mouse, clone 4G9, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Anti-Tie-2 Antibody, clone 1C5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, canine, human, monkey, mouse, rat
Application
affinity binding assay
immunocytochemistry
western blot
immunocytochemistry
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Espèce(s)
human
Proteins
Référence du produit
Description
Espèce(s)
Tie2 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.,
Espèce(s)
human
TIE2 (771-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human