MKNK2
MAP kinase interacting serine/threonine kinase 2
Synonymes:
GPRK7, MNK2
Espèce(s):
Human MKNK2 (2872), Mouse Mknk2 (17347), Rat Mknk2 (299618), sheep MKNK2 (101122519), naked mole-rat Mknk2 (101716935), domestic guinea pig Mknk2 (100734192), chicken MKNK2 (429269), domestic cat MKNK2 (101087206), cow MKNK2 (538519), dog MKNK2 (612212)
ID UniProtKB:
ID du gène:
- Human(2872) Summary: This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
- Mouse(17347) MAP kinase-interacting serine/threonine kinase 2
- Rat(299618) MAP kinase-interacting serine/threonine kinase 2
- sheep(101122519) MAP kinase interacting serine/threonine kinase 2
- naked mole-rat(101716935) MAP kinase interacting serine/threonine kinase 2
- domestic guinea pig(100734192) MAP kinase interacting serine/threonine kinase 2
- chicken(429269) MAP kinase interacting serine/threonine kinase 2
- domestic cat(101087206) MAP kinase interacting serine/threonine kinase 2
- cow(538519) MAP kinase interacting serine/threonine kinase 2
- dog(612212) MAP kinase interacting serine/threonine kinase 2
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-MKNK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
ANTI-MNK2 (MKNK2)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Anti-MKNK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-MKNK2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
dog, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-MNK2 (N-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Proteins
Numéro du produit
Description
Espèce(s)
MNK2, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human