MAPK14
mitogen-activated protein kinase 14
Synonymes:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Espèce(s):
Human MAPK14 (1432), Mouse Mapk14 (26416), Rat Mapk14 (81649), naked mole-rat Mapk14 (101715692), domestic guinea pig Mapk14 (100723285), chicken MAPK14 (421183), Horse MAPK14 (100063532), dog MAPK14 (403856), domestic cat MAPK14 (101101135), Domestic Rabbit MAPK14 (100341695) ...Plus
ID UniProtKB:
ID du gène:
- Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(26416) mitogen-activated protein kinase 14
- Rat(81649) mitogen activated protein kinase 14
- naked mole-rat(101715692) mitogen-activated protein kinase 14
- domestic guinea pig(100723285) mitogen-activated protein kinase 14
- chicken(421183) mitogen-activated protein kinase 14
- Horse(100063532) mitogen-activated protein kinase 14
- dog(403856) mitogen-activated protein kinase 14
- domestic cat(101101135) mitogen-activated protein kinase 14
- Domestic Rabbit(100341695) mitogen-activated protein kinase 14
- sheep(100217411) mitogen-activated protein kinase 14
- cow(534492) mitogen-activated protein kinase 14
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ELISA
Référence du produit
Description
Espèce(s)
Phospho-p38 α (pThr180 / pTyr182) and pan-p38 ELISA Kit, for detection of phospho-p38 alpha (pThr180 / pTyr182) and pan-p38 in human or mouse cell and tissue lysates,
Espèce(s)
human
Phospho-p38 α (pThr180 / pTyr182) ELISA Kit, fore detection of phospho-p38 alpha (pThr180 / pTyr182) in human or mouse cell and tissue lysates,
Espèce(s)
human
Cell-Based ELISA for detecting phospho-P38 MAPK (pThr180 / pTyr182) in cultured cell lines, 96 assays,
Espèce(s)
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Espèce(s)
rat, human, mouse
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-p38α (Thr180/Tyr182) Antibody, Upstate®, from rabbit,
Espèces réactives
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti- p38 MAPK antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Phospho-p38 MAPK-T180/Y182 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
western blot
western blot
Anti-phospho-p38 MAPK (pTyr182) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
Espèce(s)
human
p38α, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
Espèce(s)
human