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GRM7

glutamate receptor, metabotropic 7

Synonymes:
GLUR7, GPRC1G, MGLU7, MGLUR7
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2917) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
  • Mouse(108073) glutamate receptor, metabotropic 7
  • Rat(81672) glutamate receptor, metabotropic 7
  • Zebrafish(564461) glutamate receptor, metabotropic 7
  • chicken(416112) glutamate receptor, metabotropic 7
  • Horse(100052696) glutamate receptor, metabotropic 7
  • domestic cat(101090088) glutamate receptor, metabotropic 7
  • Domestic Rabbit(100343810) glutamate receptor, metabotropic 7
  • cow(535362) glutamate receptor, metabotropic 7
  • dog(484674) glutamate receptor, metabotropic 7

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
O-Phospho-L-serine, ,
Espèce(s)
human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Espèce(s)
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
DL-2-Amino-3-phosphonopropionic acid, ,
Espèce(s)
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Espèce(s)
rat, human
L-Glutamic acid, FCC,
Espèce(s)
rat, human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-mGluR7 Antibody, Upstate®, from rabbit,
Espèces réactives
rat
Application
western blot
Anti-GRM7 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-MGLUR7 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-GRM7 antibody produced in mouse, clone 1H5, ascites fluid,
Espèces réactives
human
Application
ELISA
western blot
Anti-Metabotropic Glutamate Receptor 7 Antibody, Chemicon®, from rabbit,
Espèces réactives
human
Application
immunohistochemistry
western blot

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Espèce(s)
rat, human
L-Glutamic acid, FCC,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Ak032068,
Espèce(s)
mouse