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CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1

Synonymes:
CACNA2, CACNL2A, CCHL2A
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(781) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(12293) calcium channel, voltage-dependent, alpha2/delta subunit 1
  • Rat(25399) calcium channel, voltage-dependent, alpha2/delta subunit 1
  • chicken(768444) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • domestic guinea pig(100728887) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • naked mole-rat(101708369) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • cow(282608) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • sheep(101123550) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • dog(610342) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • Domestic Rabbit(100009105) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • domestic cat(101099450) calcium channel, voltage-dependent, alpha 2/delta subunit 1

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Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Felodipine, solid,
Espèce(s)
human
Nifedipine, ≥98% (HPLC), powder,
Espèce(s)
rat, mouse, human
Gabapentin, solid,
Espèce(s)
human, rat
Terodiline hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-CACNA2D1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-CACNA2D1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-CACNA2D1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Calcium Channel Antibody, Voltage Gated α 2/δ-1, L-type, Chemicon®, from rabbit,
Espèces réactives
rat
Application
western blot
Anti-CACNA2D1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Isradipine, ≥98% (HPLC), solid,
Espèce(s)
human
Felodipine, solid,
Espèce(s)
human
Nifedipine, ≥98% (HPLC), powder,
Espèce(s)
rat, mouse, human
Bepridil hydrochloride, powder,
Espèce(s)
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Cacna2d1,
Espèce(s)
mouse
MISSION® esiRNA, targeting human CACNA2D1,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Cacna2d1,
Espèce(s)
mouse