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ADRA2C

adrenoceptor alpha 2C

Synonymes:
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(152) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11553) adrenergic receptor, alpha 2c
  • Rat(24175) adrenoceptor alpha 2C
  • domestic guinea pig(100135477) adrenergic receptor, alpha 2c
  • domestic guinea pig(101787589) adrenoceptor alpha 2C
  • cow(101902575) adrenoceptor alpha 2C
  • cow(407139) alpha-2C adrenergic receptor
  • sheep(100170319) adrenoceptor alpha 2C
  • Zebrafish(266752) adrenergic, alpha-2C-, receptor
  • chicken(428799) adrenergic, alpha-2C-, receptor
  • dog(488793) adrenoceptor alpha 2C
  • domestic cat(101087990) adrenoceptor alpha 2C
  • domestic cat(100529244) adrenoceptor alpha 2C

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
Clonidine hydrochloride, solid,
Espèce(s)
human
Xylazine hydrochloride, ≥99.0% (HPLC),
Espèce(s)
human
Guanfacine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Guanfacine hydrochloride, ≥98% (HPLC),
Espèce(s)
human
Guanabenz acetate salt, powder,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Espèce(s)
human
Idazoxan hydrochloride, ,
Espèce(s)
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Espèce(s)
human
UK 14,304, ,
Espèce(s)
human
Mirtazapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Apc antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Anti-Adrenergic Receptor α-2C antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 390 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 488 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Rpe antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Mianserin hydrochloride, ,
Espèce(s)
human
Agmatine sulfate salt, ≥97%, powder,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
UK 14,304, ,
Espèce(s)
human
(−)-Norepinephrine, ≥98%, crystalline,
Espèce(s)
human, rat
Haloperidol, powder,
Espèce(s)
human, rat
Clozapine, ,
Espèce(s)
human, rat

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Adra2c,
Espèce(s)
mouse