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V900731

Sigma-Aldrich

Dimethyl fumarate

Vetec™, reagent grade, 97%

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About This Item

Linear Formula:
CH3OCOCH=CHCOOCH3
CAS Number:
624-49-7
Molecular Weight:
144.13
Beilstein:
774590
EC Number:
210-849-0
MDL number:
MFCD00064438
UNSPSC Code:
12352100
PubChem Substance ID:
329830103

grade

reagent grade

product line

Vetec™

Assay

97%

bp

192-193 °C (lit.)

mp

102-106 °C (lit.)

SMILES string

[H]\C(=C(\[H])C(=O)OC)C(=O)OC

InChI

1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

InChI key

LDCRTTXIJACKKU-ONEGZZNKSA-N

Gene Information

human ... KEAP1(9817)

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Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H312,H315,H317,H335,H411

Hazard Classifications

Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBB1011
BCBH2507V

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Markus Meissner et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 10(11), 793-801 (2012-08-18)
Fumaric acid esters have been used successfully in the therapy of psoriasis vulgaris since 1959. In the last 17 years, many of the underlying mechanisms of anti-psoriatic action, such as a Th1/Th2 shift, a suppression of important leukocyte adhesion molecules
Ralf A Linker et al.
Current neurology and neuroscience reports, 13(11), 394-394 (2013-09-26)
Dimethyl fumarate is an orally available treatment option for relapsing-remitting multiple sclerosis (MS) in a new formulation with improved gastroenteric coating. The mode of action comprises immunomodulatory effects and an activation of nuclear (erythroid-derived 2) related factor mediated antioxidative response
Frieder Kees
Expert opinion on pharmacotherapy, 14(11), 1559-1567 (2013-05-24)
Dimethyl fumarate (DMF) has been used as fungicide, but oral DMF activates anti-inflammatory and anti-oxidative pathways that are beneficial in the treatment of psoriasis. BG-12, a specific formulation of DMF, has been approved very recently for the treatment of relapsing-remitting
Take-Aki Mitsudo et al.
Chemical record (New York, N.Y.), 6(3), 107-116 (2006-06-30)
The chemistry of a novel zerovalent Ru complex, Ru(eta6-cot)(eta2-dmfm)2 (1) (cot=1,3,5-cyclooctatriene; dmfm=dimethyl fumarate), is reviewed with a focus on its reactivity toward phosphines, amines, and H2O, as well as arenes and p-quinones. A variety of novel zerovalent Ru complexes were
Masanobu Tsubaki et al.
European journal of cancer (Oxford, England : 1990), 49(17), 3708-3717 (2013-08-13)
Several autocrine soluble factors, including macrophage inflammatory protein-1α and tumour necrosis factor-alpha (TNF-α), promote the survival and growth of multiple myeloma (MM) cells. We hypothesised that inhibition of the TNF-α autocrine loop may enhance the cytotoxic effect of anticancer drugs
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