11018AST
Astec® CHIROBIOTIC® V Chiral (5 μm) HPLC Columns
L × I.D. 10 cm × 2.1 mm, HPLC Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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product name
Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
material
stainless steel column
Agency
suitable for USP L88
description
HPLC Column
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
10 cm × 2.1 mm
matrix
High-purity silica gel particle platform
fully porous particle
matrix active group
vancomycin phase
particle size
5 μm
pore size
100 Å
operating pH range
3.5-7.0
separation technique
chiral
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General description
Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.
- Bonded phase: Vancomycin
- Operating pH range: 3.5 - 7.0
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography
Kosel, M., et al.
Journal of Chromatography. B, Biomedical Applications, 719 (1-2), 234-238 (1998)
HPLC separation technique for analysis of bufuralol enantiomers in plasma and pharmaceutical formulations using a vancomycin chiral stationary phase and UV detection
Hefnawy, Mohamed M., et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 856 (1-2), 328-336 (2007)
J P Bagnall et al.
Journal of chromatography. A, 1249, 115-129 (2012-07-04)
This paper presents and compares for the first time two chiral LC-QTOF-MS methodologies (utilising CBH and Chirobiotic V columns with cellobiohydrolase and vancomycin as chiral selectors) for the quantification of amphetamine, methamphetamine, MDA (methylenedioxyamphetamine), MDMA (methylenedioxymethamphetamine), propranolol, atenolol, metoprolol, fluoxetine
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