T9429
Anti-Transforming Growth Factor-β, pan antibody produced in rabbit
IgG fraction of antiserum, lyophilized powder
Synonym(s):
Anti-TGF-β, pan
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
amphibian, human, pig
technique(s)
microarray: suitable
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TGFB1(7040) , TGFB2(7042) , TGFB3(7043)
Specificity
The antibody will neutralize the biological activity of human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, human TGF-β3, and amphibian TGF-β5.
Immunogen
mixture of recombinant human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, and recombinant amphibian TGF-β5.
Biochem/physiol Actions
The effect of intraperitoneal injection of Anti-Transforming Growth Factor-β, pan antibody produced in rabbit in monocrotaline-induced pulmonary hypertension was studied in rat model.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Preparation Note
Purified using protein A.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Ya-Wen Hsiao et al.
Journal of immunology (Baltimore, Md. : 1950), 172(3), 1508-1514 (2004-01-22)
IL-6 is a multifunctional cytokine that regulates cell growth, differentiation, and cell survival. Many tumor cells produce TGF-beta1, which allows them to evade CTL-mediated immune responses. IL-6 antagonizes TGF-beta1 inhibition of CD3 cell activation. However, whether IL-6 restores NK activity
Steven M Driever et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1730) (2017-08-16)
To meet the growing demand for food, substantial improvements in yields are needed. This is particularly the case for wheat, where global yield has stagnated in recent years. Increasing photosynthesis has been identified as a primary target to achieve yield
Aikaterini J Megalou et al.
International journal of clinical and experimental medicine, 3(4), 332-340 (2010-11-13)
The role of transforming growth factor-β in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-β receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced
Samuel P Hoile et al.
PloS one, 9(10), e109896-e109896 (2014-10-21)
Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of
Tal Fisher et al.
Cell reports, 39(11), 110954-110954 (2022-06-08)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed by nsp1 as well as its functional importance are
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