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Key Documents

T6943

Sigma-Aldrich

Tyrphostin AG 112

≥90% (NMR)

Synonym(s):

3-Amino-2,4-dicyano-5-(4′-hydroxyphenyl)penta-2,4-dienonitrile, Tyrphostin A48

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About This Item

Empirical Formula (Hill Notation):
C13H8N4O
Molecular Weight:
236.23
MDL number:
MFCD00236447
UNSPSC Code:
12352200
PubChem Substance ID:
24278750

Assay

≥90% (NMR)

potency

125 nM IC50

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

NC(\C(=C/c1ccc(O)cc1)C#N)=C(\C#N)C#N

Gene Information

human ... MST1R(4486) , PTK2(5747) , PTK6(5753) , PTK7(5754) , TWF1(5756) , TXK(7294)

Biochem/physiol Actions

Protein tyrosine kinase inhibitor.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Trine Reistad et al.
Toxicological sciences : an official journal of the Society of Toxicology, 87(1), 57-65 (2005-06-17)
Polybrominated diphenyl ethers (PBDEs) are widely used brominated flame retardants (BFRs), which have become ubiquitous in the environment. This study investigates the effects of the pentabrominated diphenyl ether mixture, DE-71, on human neutrophil granulocytes in vitro. DE-71 enhanced production of

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