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T6443

Sigma-Aldrich

Tyrphostin AG 370

≥98%

Synonym(s):

2-Amino-4-(1H-indo-5′-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7

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About This Item

Empirical Formula (Hill Notation):
C15H9N5
CAS Number:
134036-53-6
Molecular Weight:
259.27
MDL number:
MFCD00236449
UNSPSC Code:
12352200
PubChem Substance ID:
329826844

Assay

≥98%

form

solid

mp

289 °C

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

NC(\C(=C/c1ccc2[nH]ccc2c1)C#N)=C(\C#N)C#N

InChI

1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,20H,19H2/b12-6-

InChI key

CMMDWEJTQUTCKG-SDQBBNPISA-N

Application

Tyrphostin AG 370 has been used for inhibiting platelet-derived growth factor (PDGF) signaling in human mesenchymal stem cells1,2.

Biochem/physiol Actions

Inhibitor of PDGF-induced cell proliferation.

Caution

Photosensitive

Preparation Note

Tyrphostin AG 370 is soluble in DMSO.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felicia Ng et al.
Blood, 112(2), 295-307 (2008-03-12)
We compared the transcriptomes of marrow-derived mesenchymal stem cells (MSCs) with differentiated adipocytes, osteocytes, and chondrocytes derived from these MSCs. Using global gene-expression profiling arrays to detect RNA transcripts, we have identified markers that are specific for MSCs and their
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose

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