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T5567

Monoclonal Anti-TCF-1 (T-Cell Factor-1) antibody produced in mouse

Name: Monoclonal Anti-TCF-1 (T-Cell Factor-1) antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone 7H3, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

MDL number:

MFCD02686647

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7H3, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen 26-48 kDa (32, 38, 42)

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
western blot: 0.5-2 μg/mL using whole extracts of Jurkat cells

isotype

IgG

UniProt accession no.

P20823

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HNF1A(6927)

Immunogen

MBP fusion protein corresponding to amino acids 109-269 of human TCF-1A splice variant.

Physical form

Solution in 0.1 M tris-glycine, pH 7.4, containing 0.15 M sodium chloride, 30% glycerol and 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells.

K Mayer et al.

International journal of cancer, 72(4), 625-630 (1997-08-07)

Physical interaction between the lymphoid high mobility group (HMG)-box architectural transcription factors TCF/LEF and beta-catenin is associated with translocation of the heteromeric complex to the nucleus and regulation of target gene expression. Since formation of molecular complexes among beta-catenin, E-cadherin

The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.

J Castrop et al.

Blood, 86(8), 3050-3059 (1995-10-15)

The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers. TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and

Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.

F J Staal et al.

International immunology, 11(3), 317-323 (1999-04-30)

Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade. Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners

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