SRP6081
TXNRD1 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
GRIM-12, MGC9145, TR1, TRXR1, Thioredoxin reductase
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human
recombinant
expressed in E. coli
Assay
≥95% (SDS-PAGE)
form
liquid
potency
0.48 units/mL
mol wt
55.7 kDa
packaging
pkg of 100 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TXNRD1(7296)
General description
Thioredoxin reductase 1 (TNXRD1), cytoplasmic is an enzyme in humans that is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases and is localized on human chromosome 12.
Biochem/physiol Actions
Thioredoxin reductase 1 (TNXRD1) reduces thioredoxins as well as other substrates. It plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses flavin adenine dinucleotide (FAD) as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, acquired immune deficiency syndrome (AIDS), autoimmune diseases as well as bacterial infections and parasitic diseases.
Physical form
0.5 mg/mL solution in PBS (pH 7.4) containing 20% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGC
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Birgitte Zeuner et al.
Enzyme and microbial technology, 82, 42-50 (2015-12-18)
Sialylated galactooligosaccharides (GOS) represent a potential infant formula ingredient, which is believed to contribute with a combination of the beneficial properties of the prebiotic GOS as well as of sialylated human milk oligosaccharides. Sialylated GOS do not exist in natural
Inés Mármol et al.
Pharmaceutics, 14(10) (2022-10-28)
In this paper we describe the synthesis of new N-heterocyclic carbene (NHC) gold(I) derivatives with flavone-derived ligands with a propargyl ether group. The compounds were screened for their antimicrobial and anticancer activities, showing greater activity against bacteria than against colon
Javier Quero et al.
Biomedicines, 9(12) (2021-12-25)
Overheating can affect solubility or lipophilicity, among other properties, of some anticancer drugs. These temperature-dependent changes can improve efficiency and selectivity of the drugs, since they may affect their bioavailability, diffusion through cell membrane or activity. One recent approach to
Nicole Swope et al.
Biotechnology and bioengineering, 117(4), 1063-1071 (2020-01-14)
Antibody disulfide bond (DSB) reduction during manufacturing processes is a widely observed phenomenon attributed to host cell reductases present in harvest cell culture fluid. Enzyme-induced antibody reduction leads to product fragments and aggregates that increase the impurity burden on the
Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis.
Zhang Z
Human Mutation, 24(5), 438-438 (2004)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service