SRP4121
IGF-I from rat
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
IGF-I, IGF1, IGFIA, Somatomedin C
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About This Item
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biological source
rat
recombinant
expressed in E. coli
Assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~7.69 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Igf1(24482)
General description
IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.
IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.
Application
IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.
IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.
Biochem/physiol Actions
IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.
IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.
Physical form
Lyophilized without additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy.
Siqueira FR
Physiology & Behavior, 154, 68-75 (2016)
The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Houshmandi N
Cytokine, 81, 117-126 (2016)
Stefano Schiaffino et al.
Skeletal muscle, 1(1), 4-4 (2011-07-30)
A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a cascade of intracellular components that mediate its effects, plays a major role in the regulation of skeletal muscle growth. A central component in this cascade is the
Elham Abdi et al.
Iranian journal of immunology : IJI, 15(1), 14-27 (2018-03-20)
IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Freund's adjuvant-induced chronic joint
María Llorens-Martín et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 15(2), 134-148 (2009-03-25)
This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one mechanism of adult neural plasticity, specifically, its regulation of hippocampal neurogenesis among other plasticity-related processes. It is suggested that IGF has been reused advantageously both for
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