Human bromodomain CREB binding protein (CREBBP), also known as CBP, RSTS and KAT3A (GenBank Accession No. NM_004380) amino acids 1081- 1197 with N-terminal His-tag, MW=14.9 kDa, expressed in an E. coli expression system.
CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition between NF-kappaB and p53 for CBP is a crucial determinant of whether a cell proliferates or undergoes apoptosis. However, how the CBP-dependent crosstalk between these two transcription
Human molecular genetics, 10(4), 395-404 (2001-02-07)
The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively. We show here that a novel t(10;16)(q22;p13) in a childhood AML
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