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SRP0385

Sigma-Aldrich

MLL1/WDR5/Ash2L/RbBP5 human

recombinant, expressed in E. coli, ≥83% (SDS-PAGE)

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥83% (SDS-PAGE)

form

aqueous solution

mol wt

27 kDa (MLL1)
35 kDa (WDR5)
60 kDa (RbBP5)
61 kDa (Ash2L)

packaging

pkg of 50 μg

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

General description

MLL1/WAR complex of human MLL1 (GenBank Accession No. NM_005933), amino acids 3745- end with N-terminal His-tag, MW= 27 kDa, human Ash2L (GenBank Accession No. NM_001105214), amino acids 2-end with N-terminal His-tag, MW= 61 kDa, and human RbBP5 (GenBank Accession No. NM_005057), amino acids 2-end with N-terminal His-tag, MW= 60 kDa, individually expressed in an E. coli expression system, and human WDR5 (GenBank Accession No. NM_017588), amino acids 2-end with N-terminal His-tag, MW= 37.4 kDa expressed in a Baculovirus Sf9 expression system.

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Man Mohan et al.
Nature reviews. Cancer, 10(10), 721-728 (2010-09-17)
The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could
Anamika Patel et al.
The Journal of biological chemistry, 284(36), 24242-24256 (2009-06-27)
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute

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