SML3932
DC-Y13-27
≥98% (HPLC)
Synonym(s):
(E)-2-cyano-3-(5-(3-hydroxyphenyl)thiophen-2-yl)acrylamide
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About This Item
Empirical Formula (Hill Notation):
C14H10N2O2S
Molecular Weight:
270.31
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 30 mg/mL, clear
storage temp.
room temp
SMILES string
NC(/C(C#N)=C/C1=CC=C(C2=CC=CC(O)=C2)S1)=O
Biochem/physiol Actions
Cell penetrant and specific inhibitor of an m6A reader YTHDF2.
DC-Y13-27 is a cell penetrant and specific inhibitor of an m6A reader YTHDF2 that overcomes MDSC(myeloid-derived suppressor cell)-induced immunosuppression and enhances combined IR and/or anti-PD-L1 treatment.
DC-Y13-27 is a cell penetrant and specific inhibitor of an m6A reader YTHDF2 that overcomes MDSC(myeloid-derived suppressor cell)-induced immunosuppression and enhances combined IR and/or anti-PD-L1 treatment.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Liangliang Wang et al.
Cancer cell, 41(7), 1294-1308 (2023-05-27)
RNA N6-methyladenosine (m6A) modification is implicated in cancer progression. However, the impact of m6A on the antitumor effects of radiotherapy and the related mechanisms are unknown. Here we show that ionizing radiation (IR) induces immunosuppressive myeloid-derived suppressor cell (MDSC) expansion
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