SML3721

PHA-680632

≥98% (HPLC)

• Synonym(s): N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-N′-{3-[4-(4-methylpiperazino)benzamide)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl}urea, PHA 680632, PHA680632
• Empirical Formula (Hill Notation): C₂₈H₃₅N₇O₂
• CAS Number: 398493-79-3
• Molecular Weight: 501.62
• MDL number: MFCD16038900
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N1(CCN(CC1)c2ccc(cc2)C(=O)Nc3n[nH]c4c3CN(C4)C(=O)Nc5c(cccc5CC)CC)C
• InChI key: OBWNXGOQPLDDPS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and selective Aurora kinase inhibitor with anti-cancer efficacy in cultures and in animals in vivo.

PHA-680632 is a potent and selective Aurora kinase inhibitor (Aurora A/B/C IC50 = 27/135/120 nM; FGFR1 IC50 = 390 nM, 30- to 200-fold selectivity for Aurora A over 6 other kinases and IC50 >10 μM against 22 kinases) with antiproliferation activity in cancer cultures (IC50 ranges from 60 nM to 7.15 μM) and anti-tumor efficacy in mice and rats in vivo (15-60 mg/kg i.v. b.i.d. or 15-45 mg/kg i.p. t.i.d.)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable