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SML3276

Sigma-Aldrich

Apelin-17 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

Apelin 17 trifluoroacetate salt, K17F trifluoroacetate salt, L-Lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine trifluoroacetate salt, Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

Apelin-17 (K17F) is a potent and selective endogenous agonist of apelin receptor (apelin-R). Apelin-17 has 16 times higher affinity for apelin-R than apelin-13 (pE13F) (Ki = 0.05 versus 0.8 nM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wang Wang et al.
Hypertension (Dallas, Tex. : 1979), 68(2), 365-377 (2016-05-25)
Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable
Adrien Flahault et al.
Nature communications, 12(1), 305-305 (2021-01-14)
Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may be beneficial for treating the Syndrome of Inappropriate Antidiuresis, in which AVP hypersecretion

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