SML3019
TH1760
≥98% (HPLC)
Synonym(s):
6-{[4-(1H-indole-5-carbonyl)piperazin-1-yl]sulfonyl}-2,3-dihydro-1,3-benzoxazol-2-one
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About This Item
Empirical Formula (Hill Notation):
C20H18N4O5S
CAS Number:
Molecular Weight:
426.45
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=S(C1=CC(O2)=C(C=C1)NC2=O)(N3CCN(CC3)C(C4=CC5=C(C=C4)NC=C5)=O)=O
Biochem/physiol Actions
TH1760 is a cell penetrant, potent and selective inhibitor of NUDT15 (NUDIX-type 15) that directly binds into the NUDT15 catalytic pocket. TH1760 sensitized cells to 6-thioguanine.
cell penetrant, potent and selective inhibitor of NUDT15 (NUDIX-type 15) that directly binds into the NUDT15 catalytic pocket
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Si Min Zhang et al.
Nature chemical biology, 16(10), 1120-1128 (2020-07-22)
The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for leukemia and inflammatory diseases. Nonetheless, its physiological roles
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