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SML1145

Sigma-Aldrich

ML303

≥98% (HPLC)

Synonym(s):

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

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25 MG
$366.00

$366.00

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25 MG
$366.00

About This Item

Empirical Formula (Hill Notation):
C21H16F3N3O2
CAS Number:
1638211-04-7
Molecular Weight:
399.37
UNSPSC Code:
12352202
PubChem Substance ID:
329825679
NACRES:
NA.77

$366.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=NN(C2=CC=C(C(F)(F)F)C=C2)C3=NC=CC(C4=CC=C(O)C(OC)=C4)=C31

InChI

1S/C21H16F3N3O2/c1-12-19-16(13-3-8-17(28)18(11-13)29-2)9-10-25-20(19)27(26-12)15-6-4-14(5-7-15)21(22,23)24/h3-11,28H,1-2H3

InChI key

YBRHGNCGFMRGSV-UHFFFAOYSA-N

Biochem/physiol Actions

It belongs to the pyrazolopyridine family.[1]
ML303 is a potent inhibitor (IC50 = 155 nM) of the influenza viral protien NS1. NS1 enhances virulence by inhibiting host cell immune responses, including the expression of IFN-b, and regulating synthesis, splicing and translation of viral RNA.
ML303 is a potent inhibitor of the influenza viral protien NS1.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
104M4702V

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Nícia Rosário-Ferreira et al.
International journal of molecular sciences, 21(4) (2020-02-27)
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according

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