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SML0489

Sigma-Aldrich

BI-87G3

≥98% (HPLC)

Synonym(s):

2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole, 2-[(5-Nitro-2-thiazolyl)thio]-benzothiazole

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About This Item

Empirical Formula (Hill Notation):
C10H5N3O2S3
CAS Number:
2207-44-5
Molecular Weight:
295.36
MDL number:
MFCD22666403
UNSPSC Code:
12352202
PubChem Substance ID:
329825439
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1cnc(Sc2nc3ccccc3s2)s1

InChI

1S/C10H5N3O2S3/c14-13(15)8-5-11-9(17-8)18-10-12-6-3-1-2-4-7(6)16-10/h1-5H

InChI key

UHBFMJAKLZGVDS-UHFFFAOYSA-N

Biochem/physiol Actions

BI-87G3 is a cell-permeable, potent and selective competitive inhibitor of the c-Jun N-terminal kinase (JNK). BI-87G3 is a JNK inhibitor that targets the JIP-JNK interaction site.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large

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