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SML0439

Sigma-Aldrich

MBCQ

≥98% (HPLC)

Synonym(s):

4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline

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About This Item

Empirical Formula (Hill Notation):
C16H12ClN3O2
CAS Number:
150450-53-6
Molecular Weight:
313.74
MDL number:
MFCD00673946
UNSPSC Code:
41106305
PubChem Substance ID:
329824721
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1

InChI

1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)

InChI key

CNODHOSDWZLJGA-UHFFFAOYSA-N

Biochem/physiol Actions

MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000192973
0000192973
0000130629
072M4626V

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Masashi Mukohda et al.
The Journal of clinical investigation, 129(6), 2318-2332 (2019-03-22)
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle-specific restoration of RhoBTB1
J F Heneghan et al.
American journal of physiology. Cell physiology, 309(5), C332-C347 (2015-06-26)
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode

Articles

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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