SAB5701779

Anti-Phospho-AMPKβ1-S108 antibody produced in rabbit

• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• species reactivity: rat, mouse, human
• concentration: 0.74 mg/mL
• technique(s): immunohistochemistry: 1:50-1:100; immunohistochemistry: 1:50-1:200; western blot: 1:2000-1:5000
• UniProt accession no.: Q9Y478
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer108)
• Gene Information: human ... PRKAB1(5564)

Description

General description

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Immunogen

A synthetic phosphorylated peptide around S108 of human AMPKβ1 (NP_006244.2).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable