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SAB4500935

Sigma-Aldrich

Anti-FOXO1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FKHR, FOXO1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, forkhead box O1A (FKHR)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 69 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q12778

UniProt accession no.

Q12778

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FOXO1(2308)

General description

Anti-FOXO1 Antibody detects endogenous levels of total FOXO1 protein.
FOXO1 (forkhead box O1) encodes a forkhead transcription factor that belongs to the Foxo subfamily. It is located on human chromosome 13q14. FOXO1 is abundantly expressed in adult pancreas and partially expressed in pancreatic β cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human FOXO1/3/4.

Immunogen Range: 15-64

Biochem/physiol Actions

FOXO1 (forkhead box O1) blocks the separation of cell in fetal pancreatic progenitor cells. It controls the differentiation of adipocyte. It plays a major role in the development and multiplication of β cell. It plays an important role in transferring insulin signaling downstream of protein kinase B.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Forkhead Protein FoxO1 Acts as a Repressor to Inhibit Cell Differentiation in Human Fetal Pancreatic Progenitor Cells
Jiang Z, et al.
Journal of Diabetes Research, 2017 (2017)
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
Daitoku H, et al.
Proceedings of the National Academy of Sciences of the USA, 101(27), 10042-10047 (2004)
The forkhead transcription factor Foxo1 regulates adipocyte differentiation
Nakae J, et al.
Developmental Cell, 4(1), 119-129 (2003)
Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
Rudzinski ER, et al.
American Journal of Clinical Pathology, 140(1), 82-90 (2013)
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
Kitamura T, et al.
The Journal of Clinical Investigation, 110(12), 1839-1847 (2002)

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