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Key Documents

SAB4300204

Sigma-Aldrich

Anti-phospho-SNCA (pTyr125) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC110988 antibody produced in rabbit, Anti-NACP antibody produced in rabbit, Anti-PARK1 antibody produced in rabbit, Anti-PARK4 antibody produced in rabbit, Anti-synuclein, alpha (non A4 component of amyloid precursor) antibody produced in rabbit

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About This Item

MDL number:
MFCD02095740
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~18 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(E-A-YP-E-M)

NCBI accession no.

NP_000336.1

UniProt accession no.

P37840

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr125)

Gene Information

human ... SNCA(6622)

Immunogen

Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M), according to the protein SNCA.

Features and Benefits

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Target description

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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