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SAB1407370

Sigma-Aldrich

Anti-IFT81 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

CDV-1, CDV-1R, CDV1, CDV1R, MGC102777, MGC4027

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~79.7 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_014055

UniProt accession no.

Q8WYA0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IFT81(28981)

Related Categories

General description

Mouse polyclonal antibody raised against a full-length human IFT81 protein. Intraflagellar transport 81 (IFT81) is part of the intraflagellar transport (IFT) B-complex. The gene encoding it is localized on human chromosome 12q24.

Immunogen

IFT81 (NP_054774.2, 1 a.a. ~ 676 a.a) full-length human protein.

Sequence
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLIL

Biochem/physiol Actions

Intraflagellar transport 81 (IFT81) associates with intraflagellar transport 74 (IFT74) to form a complex which binds to tubulin. This has a role in ciliogenesis. Mutations in the gene encoding IFT81 have been linked to ciliopathy.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene.
Higashi M
Mammalian Genome, 11(12), 1053-1057 (2000)
Isabelle Perrault et al.
Journal of medical genetics, 52(10), 657-665 (2015-08-16)
Bidirectional intraflagellar transport (IFT) consists of two major protein complexes, IFT-A and IFT-B. In contrast to the IFT-B complex, all components of IFT-A have recently been linked to human ciliopathies when defective. We therefore hypothesised that mutations in additional IFT-B
Sagar Bhogaraju et al.
Science (New York, N.Y.), 341(6149), 1009-1012 (2013-08-31)
Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells. However, the molecular mechanisms of IFT are poorly

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