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S003

Sigma-Aldrich

1-(1-Naphthyl)piperazine hydrochloride

needles

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About This Item

Empirical Formula (Hill Notation):
C14H16N2 · HCl
Molecular Weight:
248.75
MDL number:
MFCD00055161
UNSPSC Code:
12352200
PubChem Substance ID:
24278118

form

needles

color

white

solubility

H2O: soluble
ethanol: slightly soluble

SMILES string

Cl.C1CN(CCN1)c2cccc3ccccc23

InChI

1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16;/h1-7,15H,8-11H2;1H

InChI key

ZYVYPNZFOCZLEM-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Biochem/physiol Actions

5-HT1 serotonin receptor agonist; 5-HT2 serotonin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M S Herness et al.
The Journal of membrane biology, 173(2), 127-138 (2000-01-12)
Recently we reported that rat taste receptor cells respond to the neurotransmitter serotonin with an inhibition of a calcium-activated potassium current [17]. In the present study, this observation is confirmed and extended by studying the effects of an array of
R W Fuller et al.
Research communications in chemical pathology and pharmacology, 51(1), 37-45 (1986-01-01)
1-(1-Naphthyl)piperazine (1-NP) had high affinity for tritiated serotonin, tritiated LSD (lysergic acid diethylamide) and tritiated spiperone binding sites in rat brain cortex in vitro. 1-NP at doses of 3-30 mg/kg i.p. decreased 5-hydroxyindoleacetic acid (5-HIAA) concentration in whole brain of
P J Pauwels et al.
British journal of pharmacology, 123(1), 51-62 (1998-03-04)
1. The guinea-pig recombinant 5-hydroxytryptamine1B (gp 5-HT1B) receptor stably transfected in rat C6-glial cells was characterized by monitoring G-protein activation in a membrane preparation with agonist-stimulated [35S]-GTPgammaS binding. The intrinsic activity of 5-HT receptor ligands was compared with that determined
E Béjar et al.
The Journal of pharmacy and pharmacology, 47(8), 637-642 (1995-08-01)
Biphasic cumulative concentration-response curves to 5-hydroxytryptamine (5-HT) and alpha-methyl-5-hydroxytryptamine (alpha-Me-5-HT) using rat stomach fundus in the presence of 50 microM pargyline suggested two sites of interaction (high and low affinity). The order of agonist potencies of 5-HT agonists for the

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