The epitope recognized by PLA0167 maps to a region between residue 3809 and 3859 of human transformation/transcription domain-associated protein using the numbering given in entry AAD04629.1 (GeneID 8295).
TRRAP is a common component of histone acetyltransferase (HAT) complexes and functions as an adaptor protein that recruits HAT complexes to chromatin during transcription, replication, and DNA repair. TRRAP has been shown to play a key role in c-Myc-mediated transcription and transformation. TRAPP has also been observed to interact with many other transcription factors including p53, E2F1, E2F4, and the E1A viral oncoprotein.
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The EMBO journal, 39(1), e101259-e101259 (2019-09-21)
Psychiatric diseases are often accompanied by circadian disruptions, but the molecular underpinnings remain largely unclear. To address this, we screened genes that have been previously reported to be associated with psychiatric diseases and found that TRRAP, a gene associated with
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